• 姓       名:陈晓岚
  • 职       称:教授
  • 学       位:博士
  • 所在机构:郑州大学 化学与分子工程学院
  • 出生年月: 1964年12 月
  • 籍       贯:
  • 研究方向:药物化学;有机磷化学;化学生物学;绿色有机合成;绿色催化
个人简介 学术成果 发表论文

教育背景

1983-1987 郑州大学化学系本科学习;

1996-1997 英国瑞丁大学化学系留学;

2001-2004 郑州大学化学系博士研究生。

工作经历

2005-至今 郑州大学化学与分子工程学院 教授;

2010-至今 郑州大学化学与分子工程学院硕士生导师、博士生导师;

2006-2007 美国南加州大学药物化学系访问学者;

1998-2005 郑州大学化学系 副教授 硕士生导师;

1987-2000 河南医科大学基础部教师。

学术兼职

郑州大学化学与分子工程学院教授委员会委员;

河南省天方药物化学工程实验室主任;

全国磷复肥产业联盟专家。

科研项目

主持的部分国家级及省部级科研项目:

1、基于Click反应三氮唑桥连双膦酸类化合物的设计、合成研究,国家自然科学基金(No. 21072178);

2、肿瘤靶位蛋白与磷酰化黄酮的弱相互作用研究,国家自然科学基金(No. 20472076);

3、磷酰化黄酮与蛋白弱相互作用和作用位点研究,河南省杰出青年基金项目(No. 054100001400);

4、新型抗骨质疏松双膦酸药物设计、合成及工艺优化,河南省科技创新人才计划(114200510023);

5、新型三氮唑双膦酸衍生物的合成与活性研究,郑州市科技领军人才(112PLJRC359);

6、基于Click反应1,2,3-三氮唑桥连新型双膦酸类化合物的设计、合成研究,高等学校博士学科点专项科研基金(20124101110003)。

主持的国家级教学项目:

1、有机化学双语教学,2010年国家双语教学示范课程;

2、2013 来华留学英语授课品牌课程(有机化学)。

论文专著

1. Yang, Yongkang; Qu, Chen; Chen, Xiaolan*; Sun, Kai; Qu, Lingbo; Bi, Wenzhu; Hu, Hao; Li, Rui; Jing, Chunfeng; Wei, Donghui; Wei, Shengkai; Sun, Yuanqiang; Liu, Hui; Zhao, Yufen, A Multiheteroatom [3,3]-Sigmatropic Rearrangement: Disproportionative Entries into 2-(N-Heteroaryl)methyl Phosphates and α-Keto Phosphates. Org. Lett. 2017, 19 (21), 5864-5867

2. Bi, Wen-Zhu; Sun, Kai; Qu, Chen; Chen, Xiao-Lan; Qu, Ling-Bo; Zhu, Shao-Hua; Li, Xu; Wu, Hai-Tao; Duan, Li-Kun; Zhao, Yu-Fen, A direct metal-free C2-H functionalization of quinoline N-oxides: a highly selective amination and alkylation strategy towards 2-substituted quinolines. Org. Chem. Front. 2017, 4 (8), 1595-1600.

3. Zhang, Shouren; Jiang, Ruibin; Guo, Yanzhen; Yang, Baocheng; Chen, Xiao-Lan*; Wang, Jianfang; Zhao, Yufen, Plasmon Modes Induced by Anisotropic Gap Opening in Au@Cu2O Nanorods. Small 2016, 12 (31), 4264-4276.

4. Kai Sun, Xiao-Lan Chen*, Xu. Li, Ling-Bo Qu, Wen-Zhu Bi, Xin. Chen, Hui-Li Ma, Song-Tao Zhang, Bo-Wen Han, Yu-Fen Zhao, and Chao-Jun Li, H-phosphonate-mediated sulfonylation of heteroaromatic N-oxides: a mild and metal-free one-pot synthesis of 2-sulfonyl quinolines/pyridines. Chem. Commun., 2015. 51, 12111-12114.

5. Xin Chen, Xu Li, Xiao-Lan Chen*, Ling-Bo Qu, Jian-Yu Chen, Kai Sun, Zhi-Dong Liu, Wen-Zhu Bi, Ying-Ya Xia, Hai-Tao Wu, and Yu-Fen Zhao, A one-pot strategy to synthesize β-ketophosphonates: silver/copper catalyzed direct oxyphosphorylation of alkynes with H-phosphonates and oxygen in the air. Chem. Commun., 2015. 51, 3846-3849.

6. Jian-Yu Chen, Xiao-Lan Chen*, Xu Li, Ling-Bo Qu, Qing Zhang, Li-Kun Duan, Ying-Ya Xia, Xin Chen, Kai Sun, Zhi-Dong Liu, and Yu-Fen Zhao, CuSO4·5H2O-H-Phosphonate-Catalyzed Intermolecular C–S Bond Formation: Synthesis of (E)-Vinyl Alkylsulfones from Alkynes and DMSO. Eur. J. Org. Chem., 2015. 2, 314-319.

7. Xiao-Lan Chen*, Xu Li, Ling-Bo Qu, Yu-Chun Tang, Wen-Peng Mai, Dong-Hui Wei, Wen-Zhu Bi, Li-Kun Duan, Kai Sun, Jian-Yu Chen, Dian-Dian Ke and Yu-Fen Zhao, Peroxides as “Switches” of Dialkyl H-Phosphonate: Two Mild and Metal-Free Methods for Preparation of 2-Acylbenzothiazoles and Dialkyl Benzothiazol-2-ylphosphonates, J. Org. Chem. 2014, 79, 8407−8416.

8. Zhao, Wei-Ming; Chen, Xiao-Lan; Yuan, Jin-Wei; Qu, Ling-Bo; Duan, Li-Kun; Zhao, Yu-Fen, Silver catalyzed decarboxylative direct C2-alkylation of benzothiazoles with carboxylic acids. Chem. Commun. 2014, 50 (16), 2018-2020.

9. Xiaolan, Chen; Li, Xu; Qu, Zhibo; Ke, Diandian; Qu, Lingbo; Duan, Likun; Mai, Wenpeng; Yuan, Jinwei; Chen, Jianyu; Zhao, Yufen, H-Phosphonate-Mediated Amination of QuinolineN-Oxides with Tertiary Amines: A Mild and Metal-Free Synthesis of 2-Dialkylaminoquinolines. Adv. Synth. Catal. 2014, 356 (9), 1979-1985.

10. Zhang, T.; Du, J.; Liu, L.; Chen, X.; Yang, F.; Jin, Q., Inhibitory effects and underlying mechanism of 7-hydroxyflavone phosphate ester in HeLa cells. PLoS One 2012, 7 (5), e36652.

11. Chen, X. L.; Qu, L. B.; Zhang, T.; Liu, H. X.; Yu, F.; Yu, Y.; Liao, X.; Zhao, Y. F., The nature of phosphorylated chrysin-protein interactions involved in noncovalent complex formation by electrospray ionization mass spectroscopy. Anal. Chem. 2004, 76 (1), 211-7.

12. Kashemirov, B. A.; Bala, J. L.; Chen, X.; Ebetino, F. H.; Xia, Z.; Russell, R. G.; Coxon, F. P.; Roelofs, A. J.; Rogers, M. J.; McKenna, C. E., Fluorescently labeled risedronate and related analogues: "magic linker" synthesis. Bioconjug Chem2008, 19 (12), 2308-10.

奖励/荣誉

河南省自然科学优秀学术论文壹等奖1项;

河南省自然科学优秀学术论文贰等奖4项;

河南省自然科学优秀学术论文叁等奖4项;

河南省优秀硕士论文指导老师2项。